Multi-Symptom Inflammatory Syndrome in Children (MSI-C)

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What is Multi-Symptom Inflammatory Syndrome in Children (MSI-C)?

The Pediatric Group - Multi-Symptom Inflammatory Syndrome in Children (MSI-C)

Multi-system Inflammatory Syndrome in Children (MIS-C) is a condition where different body parts can become inflamed, including the heart, lungs, kidneys, brain, skin, eyes, or gastrointestinal organs. Children with MIS-C may have a fever and various symptoms, including abdominal (gut) pain, vomiting, diarrhea, neck pain, rash, bloodshot eyes, or feeling extra tired. We do not yet know what causes MIS-C. However, many children with MIS-C had the virus that causes COVID-19, or had been around someone with COVID-19.

We partner with Children's National Medical Center to evaluate and care for MIS-C, as well as other serious illnesses. 

Children with MIS-C can have a variety of symptoms, including:

  • Fever
  • Abdominal pain
  • Vomiting
  • Diarrhea
  • Neck pain
  • Rash
  • Bloodshot eyes
  • Feeling extra tired

We do not yet know what causes MIS-C, however many children with MIS-C have tested positive for COVID-19. While MIS-C is a serious condition, with proper medical care most children are able to recover. If you have concerns your child is suffering from MIS-C, please call us immediately at 410-721-2273.

If your child presents these more severe versions of MIS-C symptoms, please seek emergency care immediately:

  • Trouble breathing
  • Pain or pressure in the chest that does not go away
  • New confusion
  • Inability to wake or stay awake
  • Bluish lips or face
  • Severe abdominal pain

The link between MIS-C and COVID-19 is evolving every day, and pediatricians and researchers at Children’s National and the Centers for Disease Control (CDC) are working tirelessly to understand its current and long-term effects on children. For additional information, please visit the CDC page on MIS-C.


Children's National Medical Center

Centers for Disease Control and Prevention

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